World Arthritis day is held on the 12th of October annually, it is a global initiative to raise awareness of the importance of early diagnosis and timely access to evidence-based treatment. Established in 1996, World Arthritis Day currently works to support the 350 million people that have been diagnosed with Arthritis.1
Arthritis is an inflammation of the joints. It can affect one joint or multiple joints. Though most commonly seen in adults over the age of 65, it can also develop in children with 1 In 250 being diagnosed with arthritis.2 Two of the most common types of Arthritis are:
- Osteoarthritis – The most common type of arthritis, occurs when the surface within your joints become damaged so the joint doesn’t move as smoothly as it should, causing joints to feel stiff and painful.
- Rheumatoid Arthritis – an autoimmune disease, that causes inflammation with the joints by a build-up of fluid and cells in the synovium.3
Studies have shown that TH17 cells including GM-CSF, TNHa and IL-17 are key markers of inflammation. Specifically, levels of GM-CSF have been shown to be elevated in synovial fluid and plasma of Rheumatoid Arthritis patients.
In mouse models of arthritis, GM-CSF deficiency or neutralisation prevented the development of arthritis and reduced the concentrations of TNF and IL-1 in joints. Conversely, GM-CSF administration exacerbated arthritis.4
Randox Biosciences Product Offerings
For 35 years, Randox Biosciences have been developing and manufacturing polyclonal and monoclonal antibodies, proteins and antibody fragments (sdAb, scFv, Fab) for use in Randox diagnostic kits including our proprietary Biochip Array Technology and ELISA testing kits.
We offer a wide range of inflammatory cytokine markers including:
- Interleukin 17 (IL-17)
- Interferon γ (IFNγ)
- Tumour necrosis factor α (Tnfα)
- Granulocyte macrophage colony-stimulating factor (GM-CSF)
Using some of our resources, we have also developed cytokine arrays that are utilised on our award-winning patented Biochip Array Technology. As cytokines play a central role in the immune system and are involved in a variety of immunological, inflammatory and infectious diseases, they have been linked to many disease states including arthritis.
There are many key benefits of Randox Biosciences Cytokine Array, these consist of:
- Multiplex testing from a single sample
- Small sample volume
- Suitable for human serum, plasma samples
- Excellent analytical performance
- Fast throughput
- Applicable to fully automated and semi-automated evidence analysers
Would you like more information on our capabilities? Email us at email@example.com
1 – World Arthritis Day
2 – Arthritis Foundation
3 – Arthritis Research
4 – Biomed Central
*for research use only